- 2025年度

  1. Hirota Y, Sato T, Watanabe R, Takeda K, Sano S, Asano S, Shibahashi Y, Yasuda Y, Takagi Y, Yamashita Y, Wu Y, Arakawa M, Maitani Y, Lawai　V, Nakagawa K, Furukawa N, Takeuchi A,  Tode C, Kamao M, Wada A, Ngaini Z, Suhara Y.
    A New Class of Vitamin K Analogues Having a Hybrid Structure with the Side Chain of Retinoic Acid to Enhance the Neuronal Differentiation-Inducing Activity.
    JMC in submitted (2025)
  2. Hirota Y,et al.
    PI5P4K inhibitors…
    FEBS J. in press (2025)
  3. Hirota Y*,et al. Review

    BMCL in preparation (2025)
  4. Hirota Y*,et al. VK

    BBRC in preparation (2025)
  5. Hirota Y*,et al. VD

    in preparation (2025)
  6. Sano S, Hirota Y*, et al.

    FEBS J. in preparation (2025)
  7. Tagami S, Hirota Y*, et al.

    in preparation (2025)

- 2024年度

  1. Koharazawa R, Hayakawa M, Takeda K, Miyazaki K, Tode C, Hirota Y, Suhara Y.
    Exploring 2-methyl-substituted vitamin K3 derivatives with potent inhibitory activity against the 3CL protease of SARS-CoV-2
    Bioorg. Med. Chem. Lett., 100, 129642 (2024)
  2. Kofuji S, Wolfe K, Sumita K, Kageyama S, Yoshino H, Hirota Y, Ogawa-Iio A, Kanoh H, Sasaki M, Kofuji M, Davis MI, Pragani R, Shen M, Boxer MB, Nakatsu F, Nigorikawa K, Sasaki T, Takeuchi K, Senda T, Kim SM, Edinger AL, Simeonov A, Sasaki AT
    A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion
    Biochem. Biophys. Res. Commun., 718 149981 (2024)
  3. Arai T+, Oshima M+, Uemura M, Matsunaga T, Ashizawa T, Suhara Y, Yoneyama H, Usami Y, Harusawa S, Komeda S, Hirota Y* +.
    Azolato-bridged dinuclear platinum(II) complexes exhibit androgen receptor–mediated anti–prostate cancer activity
    Inorg Chem., 63 in press (2024)

- 2023年度

  1. Furukawa N, Chen X, Asano S, Matsumoto M, Wu Y, Murata K, Takeuchi A, Tode C, Homma T, Koharazawa R, Usami K, Tie JK, Hirota Y, Suhara Y.
    Synthesis of new vitamin K derivatives with a ketone group at the C-1′ position of the side chain and their conversion to menaquinone-4.
    J. Mol. Struct., 1276, 134614 (2023)
  2. Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT.
    Multimodal Action of KRP203 on Phosphoinositide Kinases in vitro and in cells.
    Biochem. Biophys. Res. Commun., 679, 116-121 (2023)
  3. Homma T, Okamoto M, Koharazawa R, Hayakawa M, Fushimi T, Tode C, Hirota Y, Osakabe N, Baba M, Suhara Y.
    Exploring Novel Vitamin K Derivatives with Anti-SARS-CoV2 Activity
    ACS Omega, 8, 42248−42263 (2023)
  4. Hirota Y*
    Elucidation of physiological functions of vitamin K in the brain and development of new derivatives for neuroregeneration.
    Yakugaku Zasshi, 143, 199-203 (2023)
  5. 小林正知、佐野翔、新井佑、村田昂平、田上晋太朗、渡邉莉菜、須原義智、廣田佳久*
    ビタミンK変換酵素UBIAD1はコレステロール代謝酵素HMG CoA還元酵素の小胞体関連分解を制御する
    ビタミン誌, 97, 84-87 (2023)
  6. 佐野翔、新井佑、清野航、渡邉莉菜、本間大暉、鎌尾まや、須原義智、廣田佳久*
    ビタミンK変換酵素UBIAD1の変異により引き起こされるSchnyder corneal dystrophyの発症機構
    ビタミン誌, 97, 275-279 (2023)
  7. 本間大暉、早川真由、廣田佳久、須原義智
    脂溶性ビタミンとSARS-CoV-2に関する最近の知見
    ビタミン誌, 97, 280-284 (2023)
  8. 田上晋太朗、浅野公志、中川胡桃、富岡涼、村田昂平、大島将、鎌尾まや、西川美宇、 生城真一、廣田佳久*
    メナジオンは第Ⅱ相薬物代謝酵素群により解毒代謝される
    ビタミン誌, 97, 518-522 (2023)

- 2022年度

  1. Ikeda Y, Hirayama A, Kofuji S, Hirota Y, Kamata R, Osaka N, Fujii Y, Sasaki M, Ikeda S, Smith EP, Bachoo R, Soga T, Sasaki AT.
    SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides.
    J. Biochem., 170, 699-711 (2022)

- 2021年度

  1. Dasgupta B, Hirota Y, Fujii Y, Osaka N, Ito D, Plas D, Sasaki A.
    Targeting Energy Metabolism to Overcome Therapeutic Resistance of Glioblastoma and Tumor-associated Edema.
    Gliomas, Chapter 7, 121-137 (2021)
  2. Garrett M, Fujii Y, Osaka N, Ito D, Hirota Y, Sasaki A.
    Emerging Roles of Wild-type and Mutant IDH1 in Growth, Metabolism and Therapeutics of Glioma.
    Gliomas, Chapter 4, 61-78 (2021)
  3. Sengupta S, Pater L, Krummel D, Aronow B, Hirota Y, Phoenix T, Sasaki A.
    Integration of Molecular Analysis, Cutting-edge Mouse Genetic Models and Proton Therapy to Improve Outcomes for Glioma Patients.
    Gliomas, Chapter 5, 79-95 (2021)
  4. Osaka N, Hirota Y, Ito D, Ikeda Y, Kamata R, Fujii Y, Chirasani VR, Campbell SL, Takeuchi K, Senda T, Sasaki AT.
    Divergent mechanisms activatingRAS and small GTPases through posttranslational modification 1outside the Switch regions.
    Front. Mol. Biosci., 8, 707439 (2021)

- 2020年度

  1. Yoshimura H+, Hirota Y+, Soda S, Okazeri M, Takagi Y, Takeuchi A, Tode C, Kamao M, Oksakabe N, Suhara Y.
    Study on structure-activity relationship of vitamin K derivatives: conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity.
    Bioorg. Med. Chem. Lett., 30, 127059 (2020)
  2. Nishikawa M, Yasuda K, Takamatsu M, Abe K, Okamoto K, Horibe K, Mano H, Nakagawa K, Tsugawa N, Hirota Y, Horie T, Hinoi E, Okano T, Ikushiro S, Sakaki T.
    Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions.
    Sci. Rep., 10, 5677 (2020)

- 2019年度

  1. Hirota Y, Suhara Y.
    New aspects of vitamin K research with synthetic ligands: transcriptional activity via SXR and neural differentiation activity.
    Int. J. Mol. Sci., 20, pii: E3006 (2019)
  2. Nishikawa M, Yasuda K, Takamatsu M, Abe K, Nakagawa K, Tsugawa N, Hirota Y, Tanaka K, Yamashita S, Ikushiro S, Suda T, Okano T, Sakaki T.
    Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes.
    J. Steroid Biochem. Mol. Biol., 185, 71-79 (2019)
  3. Tsutsumi A, Horikoshi Y, Saito A, Koizum R, Fujii Y, Hu QQ, Hirota Y, Aizawa K, Osakabe N.
    Acylated anthocyanins derived from purple carrot (Daucus carota L.) induce postprandial elevation of blood flow in rat cremaster arteriole.
    Food. Chem., 10, 1726-1735 (2019)
  4. Fujii Y, Suhara Y, Sukikara Y, Teshima T, Hirota Y, Yoshimura K, Osakabe N.
    Elucidation of the Interaction between Flavan-3-ols and Bovine Serum Albumin and Its Effect on Their In-Vitro Cytotoxicity.
    Molecules, 24, pii: E3667 (2019)
  5. Nishioka T, Endo-Umeda K, Ito Y, Shimoda A, Takada N, Takeuchi A, Tode C, Hirota Y, Oksakabe N, Makishima M, Suhara Y.
    Synthesis and in vitro evaluation of novel liver X receptor α-selective agonists based on naphthoquinone derivatives.
    Molecules, 24, pii: E4316 (2019)

- 2018年度

  1. Hirota Y*, Nakagawa K, Isomoto K, Sakaki T, Kubodera N, Kamao M, Osakabe N, Suhara Y, Okano T.
    Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.
    Plos One., 13, e0199856 (2018) 1-20 *Corresponding author
  2. 廣田佳久
    ビタミンKの生体内代謝機構に関する研究
    ビタミン誌, 92, 63-72 (2018)
  3. 須原義智，廣田佳久
    ビタミンK研究のパラダイムシフト吸収・代謝から新たな生物活性まで,
    化学と生物, 56, 26-32 (2018)

- 2017年度

  1. Hirota Y*, Suhara Y, Osakabe N, Sakaki T*, Okano T*.
    25-hydroxyvitamin D3 may Function via Genomic and Non-Genomic actions.
    Anat. Physiol., 7, 278-280 (2017) *Corresponding author
  2. Sakane R+, Hirota Y+, Kimura K+, Ishizawa M, Takagi Y, Wada A, Kuwahara S, Makishima M, Suhara Y.
    Synthesis of novel vitamin K derivatives introduced alkylated phenyl group at ω-terminal side chain and evaluation of their neural differentiation activities.
    Bioorg. Med. Chem. Lett., 27, 4881-4884(2017)
  3. Kimura K, Hirota Y, Kuwahara S, Takeuchi A, Tode C, Wada A, Osakabe N, Suhara Y.
    Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group that Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells.
    J. Med. Chem., 60, 2591-2596 (2017)
  4. Kamao M, Hirota Y, Suhara Y, Tsugawa N, Nakagawa K, Okano T, Hasegawa H.
    Determination of Menadione by Liquid Chromatography-Tandem Mass Spectrometry Using Pseudo Multiple Reaction Monitoring.
    Anal. Sci., 33, 863-867 (2017)
  5. Ito M, Kudo N, Miyake Y, Imai T, Unno T, Yamashita Y, Hirota Y, Ashida H, Osakabe N.
    Flavan 3-ols delays the progression of disuse atrophy induced by hindlimb suspension in mice.
    Exp. Gerontol., 98, 120-123 (2017)
  6. 廣田佳久，中川公恵，澤田夏美，奥田直子，須原義智，内野由理，木本貴士，舟橋伸昭，鎌尾まや，津川尚子，岡野登志夫
    ビタミンK合成酵素UBIAD1タンパク質の機能解析
    ビタミン誌, 91, 348-351 (2017)
  7. 廣田佳久，伊東優貴，須原義智
    ビタミンD はSREBP/SCAP の分解を誘導することで脂質代謝を制御する,
    ビタミン誌, 91, 617-620 (2017)
  8. 木村キミト，廣田佳久，桑原重文，竹内敦子，都出千里，和田昭盛，越阪部奈緒美，須原義智
    神経幹細胞からニューロンへの分化を高選択的に誘導するヘテロ原子を導入したビタミンK誘導体の合成,
    ビタミン誌, 91, 499-502 (2017)

- 2016年度

  1. Hirota Y*, Nakagawa K, Mimatsu S, Sawada N, Sakaki T, Kubodera N, Kamao M, Tsugawa N, Suhara Y, Okano T*.
    Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice.
    Biochem. Biophys. Res. Commun., 483, 359-365 (2017) *Corresponding author

- 2015年度

  1. Hirota Y*, Nakagawa K, Sawada N, Okuda N, Suhara Y, Uchino Y, Kimoto T, Funahashi N, Kamao M, Tsugawa N, Okano T*.
    Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1.
    PLoS One, 10, e0125737 (2015) *Corresponding author
  2. Suhara Y, Hirota Y, Hanada N, Nishina S, Eguchi S, Sakane R, Nakagawa K, Wada A, Takahashi K, Tokiwa H, Okano T.
    Synthetic small molecules derived from natural vitamin K homologues that induce selective neuronal differentiation of neuronal progenitor cells.
    J. Med. Chem., 58, 7088-7092 (2015)
  3. Funahashi N, Hirota Y, Nakagawa K, Sawada N, Watanabe M, Suhara Y, Okano T.
    YY1 positively regulates human UBIAD1 expression.
    Biochem. Biophys. Res. Commun., 460, 238-44 (2015)
  4. Hirota Y.
    Physiological role of vitamin K2 converting enzyme UBIAD1.
    Research reports of Suzuka University of Medical Science, 22, 1-17 Review (2015)
  5. 廣田佳久, 野田誠司, 西田恵里, 北村幸大, 原田均, 須原義智, 岡野登志夫
    ユビキノン生合成酵素UbiAの結晶構造
    ビタミン誌, 89, 579-582 (2015)

- 2014年度

  1. Nakagawa K, Sawada N, Hirota Y, Uchino Y, Suhara Y, Hasegawa T, Amizuka N, Okamoto T, Tsugawa N, Kamao M, Funahashi N, Okano T.
    Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice.
    PLoS One, 9, e104078 (2014)
  2. Nakagawa K, Hirota Y, Tsugawa N, Uchino Y, Suhara Y, Okano T.
    Menaquinone-4 (Vitamin K2) in Bone Originates from Menadione (Vitamin K3) Released from Oral Phylloquinone (Vitamin K1) During Intestinal Absorption.
    J. Bone Miner. Res., 29, S250 (2014)

- 2013年度

  1. Hirota Y, Tsugawa N, Nakagawa K, Suhara Y, Tanaka K, Uchino Y, Takeuchi A, Sawada N, Kamao M, Wada A, Okitsu T, Okano T.
    Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats.
    J. Biol. Chem., 288, 33071-33080 (2013)
  2. Okano T, Hirota Y, Nakagawa K, Funahashi N, Watanabe M.
    Gene structure analysis of a novel human menaquinone-4 biosynthetic enzyme UBIAD1 that regulates osteoblast function.
    Osteoporosis international, 24, S242 (2013)
  3. 廣田佳久, 中川公恵, 須原義智, 岡野登志夫
    UBIAD1により合成されたmenaquinne-4は血管の恒常性維持を担う
    ビタミン誌, 87, 691-695 (2013)

- 2012年度

  1. Nickerson ML, Bosley AD, Weiss JS, Kostiha BN, Hirota Y, Brandt W, Esposito D, Kinoshita S, Wessjohann L, Morham SG, Andresson T, Kruth HS, Okano T, Dean M.
    The UBIAD1 Prenyltransferase Links Menaquione-4 Synthesis to Cholesterol Metabolic Enzymes.
    Hum. Mutat., 34, 317-329 (2012)
  2. Suhara Y, Motoyoshi S, Hirota Y, Sawada N, Nakagawa K, Tokiwa H, Okano T.
    Structure-activity relationship of novel vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists.
    Yakugaku Zasshi, 132, 881-886 (2012)
  3. 中川公恵, 廣田佳久, 澤田夏美, 内野由理, 須原義智, 岡野登志夫
    ビタミンK2（メナキノン-4）生合成酵素の構造と機能解析
    Osteoporosis Japan, 20, 25-30 (2012)
  4. 中川公恵, 廣田佳久, 澤田夏美, 内野由理, 須原義智, 岡野登志夫
    ビタミン K2（メナキノン-4）生合成酵素の発見
    ビタミン誌, 86, 441-444 (2012)

- 2011年度

  1. 岡野登志夫, 中川公恵, 廣田佳久, 澤田夏美
    ビタミンKの代謝活性化と骨作用の分子機構～骨形成を助けるビタミンK2変換酵素の発見
    化学と生物（日本農芸化学会和文誌）, 49, 372-374 (2011)

- 2010年度

  1. Nakagawa K, Hirota Y, Sawada N, Yuge N, Watanabe M, Uchino Y, Okuda N, Shimomura Y, Suhara Y, Okano T.
    Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme.
    Nature, 468, 117-121 (2010)

- 2008年度

  1. Suhara Y, Hirota Y, Nakagawa K, Kamao M, Tsugawa N, Okano T.
    Design and synthesis of biologically active analogues of vitamin K2 evaluation of their biological activities with cultured human cell lines.
    Bioorg. Med. Chem., 16, 3108-3117 (2008)